(This Blog is dedicated to my beloved father Sh. GOVIND RAM)

Welcome to the first Blog on the web dedicated to Liver Transplant in India Information. For A-Z Gastroentorlogy Disorders, Digestive Diseases, "J-Pouch" Operation, Yoga, Naturopathy,& Ayurvedic Treatments, Visit: http: //anshugpta.blogspot.com, For Healthy Life Style, Beauty Tips, Fashion Tips, Yoga, Naturopathy, Ayurvedic & Medical Knowledge, Herbal Remedies, Ayurvedic Herbs, Natural Cosmetics, Rejuvenation Therapies, Herbal Diet, Meditation, Yoga Styles, Men's Health & Women's Health Topics, Health Calculators and more.. Visit: http://yourhealthinformation.blogspot.com

Advertise Now

Blog Archive

Can't Find What You're Looking For?

Tuesday, January 22, 2008

Alpha-1-Antitrypsin Deficiency

Alpha -1 Antitrypsin (AAT) deficiency
One of the most common inherited disorders among caucasians. Incidence is 1 per 2-7000 population. The phenotypic variations in AAT gene is expressed as the Protease inhibitor (Pi) alphabetical nomenclature. The Pizz variant most often characterizes the ATT deficiency state. Among Pizz infants with jaundice 25% will experience cirrhosis within the first decade of life, 25% will show persistent liver enzyme elevation progressing to cirrhosis in the second decade, 25% will resolve the biochemical change completely and show only mild fibrosis on biopsy. The liver injury in all these cases is probably attributed to release of proteases.

Liver transplantation normalizes serum ATT levels and hence none of the transplanted patients develop lung injury and emphysema.

No comments: