(This Blog is dedicated to my beloved father Sh. GOVIND RAM)

Welcome to the first Blog on the web dedicated to Liver Transplant in India Information. For A-Z Gastroentorlogy Disorders, Digestive Diseases, "J-Pouch" Operation, Yoga, Naturopathy,& Ayurvedic Treatments, Visit: http: //anshugpta.blogspot.com, For Healthy Life Style, Beauty Tips, Fashion Tips, Yoga, Naturopathy, Ayurvedic & Medical Knowledge, Herbal Remedies, Ayurvedic Herbs, Natural Cosmetics, Rejuvenation Therapies, Herbal Diet, Meditation, Yoga Styles, Men's Health & Women's Health Topics, Health Calculators and more.. Visit: http://yourhealthinformation.blogspot.com

Advertise Now

Blog Archive

Can't Find What You're Looking For?

Monday, February 25, 2008

IgA nephropathy (Berger’s disease)

Definition:

IgA nephropathy is a kidney disorder characterized by blood in the urine . It is caused by inflammation of internal kidney structures and the deposit of IgA antibodies in kidney tissue.

Alternative Names:

Nephropathy - IgA; Berger's disease

Causes, incidence, and risk factors:

IgA nephropathy (Berger's disease) is a form of mesangial proliferative nephritis. Structures in the kidney called glomeruli become inflamed, and a type of antibody called IgA deposits in the kidney. The disorder can appear as acute , rapidly progressive, or chronic glomerulonephritis , or as visible or microscopic blood in the urine.
IgA nephropathy usually is discovered after one or more episodes of dark or bloody urine in a person with no other symptoms of kidney disorder. Bloody urine may begin during or soon after a respiratory infection. Acute nephritic syndrome or nephrotic syndrome (groups of symptoms associated with decreased kidney functioning) may result.
Risk factors include having a personal or family history of IgA nephropathy or Henoch Schonlein purpura (a form of vasculitis that affects many parts of the body, and may cause a kidney lesion that is identical to the lesion of Berger's disease).
IgA nephropathy can occur in persons of all ages, but most often affects males in their teens to late 30s.

Symptoms:

  • Changes in color of urine - bloody, dark, brown, or rust colored
  • Repeated episodes of dark or bloody urine

Signs and tests:

There are no specific changes seen during a physical examination. Occasionally, blood pressure may be elevated or swelling of the body may be present.
  • Urinalysis shows blood and red cell casts in the urine , and may also show protein and fats.
  • Kidney biopsy shows deposits of IgA antibodies and confirms the diagnosis.
  • Urine immunoelectrophoresis shows antibodies to IgA.

Treatment:

The goal of treatment is to relieve symptoms and prevent or delay chronic renal failure
Antihypertensive (high blood pressure) medications and diuretics may be given to control high blood pressure and edema . Control of blood pressure is the most important measure to delay renal (kidney) damage. Sodium (salt) and fluids may be restricted to control swelling . A low- to moderate- protein diet may be recommended in some cases.
The use of ACE inhibitors is key to preventing this disease from getting worse. Corticosteroids, other immunosuppressive drugs, and fish oil have also been used to treat this disorder.

Support Groups:

For additional information and support, see the IgA Nephropathy Support Network website ( www.igansupport.org ).

Expectations (prognosis):

IgA nephropathy progresses slowly. In many cases, it does not progress at all. High blood pressure, large quantities of protein in the urine , and increased BUN or creatinine levels (blood tests that reflect kidney functioning) indicate a higher risk for progression of the disorder.
About 25% of people with IgA nephropathy develop end-stage kidney failure within about 25 years.

Complications:

  • Chronic kidney failure
  • End-stage kidney disease

Calling your health care provider:

Call your health care provider if you have bloody urine or if your urine output decreases.

No comments: