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Wednesday, May 28, 2008

Radioisotope scans Q&As

My daughter is pregnant and she has just had cancer diagnosed. If she needs any x-rays and scans will she still be able to have these even though she is pregnant?

Cancer is diagnosed during about 1 in every 1000 pregnancies. This means that the combination of cancer and pregnancy is uncommon. However, when it does occur it is a situation which raises many questions.

The benefits to the mother of any scans and x-rays must be balanced against the possibility of any harm to her unborn child. Another issue is that because cancer during pregnancy is so unusual there is relatively little information available and this can lead to uncertainty over the best way to handle the problem.

So the pattern of care for anyone who is found to have cancer during her pregnancy is likely to be worked out on an individual basis. The doctors will take account of such things as

  • the type of cancer
  • how big it is
  • whether it has spread
  • the stage of the pregnancy
  • the different types of treatment that could be used
  • and the feelings and wishes of the mother, her partner and their relatives.

Having said this, it is possible to make some general comments about the use of scans and x-rays during pregnancy. But before this it might be helpful to describe the various stages in the progress of a normal pregnancy. These are:

  • preimplantation: this is the time from when fertilisation of the female egg (ovum) takes place until the fertilised egg becomes firmly attached to the wall of the womb (the uterus). This usually takes about 8 days.
  • embryonic stage: this is the period during which the embryo develops and all the major organs of the body are formed (so it is also known as the period of organogenesis). This usually lasts from the 8th day to about the 8 the week of the pregnancy).
  • foetal stage: during this time, the various organs that have been formed grow in size and become increasingly mature. Although most of the body's organs will have been formed during the embryonic phase a few important tissues are still developing during the foetal period, these include the nerves, the lung tissue and the bone marrow. The foetal stage lasts from the 8th week until the time of birth, at about 38 weeks.
A normal pregnancy lasts about 38 weeks and another way that is used to describe its progress is to talk about three 'trimesters', each trimester being about twelve weeks. So the first trimester covers the period of preimplantation, the development of the embryo and the beginning of foetal growth. The second trimester covers the early and middle stage of foetal growth and third trimester covers the final three months, til birth.

Any damage to the unborn child can lead to a number of different outcomes. These include:
  • spontaneous abortion during the early part of the pregnancy
  • a child born with congenital malformations or birth defects
  • premature birth with the child being delivered early
  • a low birth weight
  • problems which appear during childhood or adolescence, such as delayed growth, difficulties with learning and infertility
  • an increased risk of cancer development in later life.

This list looks alarming but it is important to remember that many of these problems occur with 'normal' pregnancies when there are no other illnesses or treatments involved. For example, it is estimated that between 1 in 8 to 1 in 10 pregnancies end in a miscarriage or spontaneous abortion, that about 1 in 50 babies are born with obvious birth defects or congenital abnormalities and about 1 in 10 have very minor, less obvious abnormalities.

Tests for someone with cancer are used to check on the size of the growth and whether or not is has spread. They may include: ordinary x-rays (like a chest x-ray), ultrasound scans, CT scans (also known as CAT scans or computerised scans), magnetic resonance imaging (MRI scans), radio-isotope scans (like bone scans) and positron emission tomography (PET scans).

The main concern over tests in pregnancy is whether they involve the use of ionising radiation. In high doses, radiation can be damaging to the unborn child, particularly during the first few weeks of pregnancy.

X-rays, CT scans, radio-isotope scans and PET scans involve the use of ionising radiation. The doses of radiation involved are small so the risk of damage to the unborn child is likely to be small. However, doctors try to avoid using these tests during pregnancy, especially during the first trimester. The one exception is a chest x-ray with protective shielding to the pelvic region. The dose to the foetus from this is so tiny that it is considered to be a 'safe' test.

Ultrasound scans and MRI scans do not use ionising radiation and there is no recorded evidence that they can cause any harm to the embryo or the foetus. So usually any 'imaging' tests that need to be done for a woman who is pregnant and who has cancer can be safely and effectively done using a combination of a chest x-ray and appropriate ultrasound and MRI scans.

Sentinel node biopsy testing is sometimes used in breast cancer or malignant melanoma to discover whether the cancer has spread to nearby lymph nodes. During this test a very small dose of radioactive material may be used. Specialists hold different views on whether this test is safe for use in pregnancy. Some feel that as the dose is so tiny the risk to the unborn child is negligible and the test is safe to use. Other doctors feel that this test should be avoided in pregnant women.

For each woman the doctors will work towards a safe and effective, pattern of tests, to get the information needed to plan her treatment. Obviously the woman and her family should be involved in discussions about what choices there are. In this way the final plan of action will offer the best possible chances of success for the mother with the least possible risk of harm to her unborn child.

I am going to have a bone scan. They tell me I will have a radio-active injection before the scan. This is worrying me.

A bone scan test involves having an injection of a minute dose of radioactive material (usually a substance called technetium) into a vein. You then have to wait for a couple of hours while this is taken up in the bones. You then lie on a bed by a large camera which takes special pictures of the bones. This usually only takes a few minutes.

The dose of radio-active material used in the test is very small and will virtually have disappeared from your body within twenty four hours of the injection.

This means there will not be any side-effects from the injection.

For a few hours, however, you will have a small dose of radiation in your tissues. Although the risks from this are negligible, to be absolutely safe, it is often recommended that you don't come into close contact with very young children or pregnant women for twenty four hours after the injection. A further routine precaution is that bone scans are not done if a woman is pregnant.

So you can go ahead with the test, safe in the knowledge that there is no evidence that anyone has ever been harmed by the radiation from a bone scan injection.

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