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Friday, November 28, 2008

Rex Shunt

For portal hypertension there are different surgical options.

Two basic surgical choices include palliative shunts, which essentially decrease the severity of symptoms, and restorative shunts, which restore normal blood flow through the liver.

About rex shunt?

Use of the restorative shunt, the meso-rex bypass — or "rex shunt" for short.
Because the rex shunt restores normal blood flow to an otherwise normal liver, it is believe that this is the treatment of choice for children with extra-hepatic portal vein thrombosis (EHPVT).

The shunt bypasses the blocked portal vein and restores venous blood flow to the liver. A vein (usually the jugular vein in the neck) is used to build a bridge around the blockage. Blood flows from the large intestinal veins, across the bridge, around the blockage and back into the liver. Blood can then flow from the intestines into the liver in the "normal" way.

Following the surgery, the symptoms of portal hypertension usually resolve very quickly. It is also believe that restoration of normal portal blood flow to the liver allows the liver to recover some of the functions that may have been impaired because of the obstruction thereby allowing the child to grow and develop to their full potential.

Wednesday, November 26, 2008

Portal Vein Thrombosis

What is the portal vein?

The portal vein is a very large vein in the abdomen which is responsible for carrying blood from the bowels and other abdominal organs to the liver.

Why is it medically important?


For some unknown reason(s) the portal vein is prone to developing a blood clot. This blood clot usually completely blocks the portal vein. When the vein is blocked, it causes blood to back up in the vein causing high pressures in all the veins below it. The condition is medically known as portal vein thrombosis (PVT). In addition, the organs returning blood to the portal vein, like the spleen, get engorged with blood. In many cases, the body attempts to bypass this blocked vein by developing thin walled veins (collaterals). These collaterals are large and appear like varicosities. The majority of these varicose veins are seen at the lower end of the esophagus (eating tube) but may appear anywhere in the abdomen.

How common is portal vein thrombosis (PVT)?

In the US, PVT is a relatively rare condition with an overall incidence of 5 per 10,000 individuals. The highest incidence of portal vein thrombosis is in Africa and India- probably due to a high incidence of liver infections, parasites and liver cancers. The condition occurs in all ethnic groups and there are no sex differences.

What conditions are associated with PVT?

- Heart failure

- Budd chiari (a childhood condition)

- Constrictive pericarditis (the heart is encased with a stiff covering which

Prevents the heart from beating well)

- Live cirrhosis or scarring

- Cancers of the liver, pancreas, stomach and bile ducts

- Pus in the liver

- Infection of the pancreas (Pancreatitis)

- Infection of the umbilical cord (in babies)

- Pregnancy-pre eclampsia

- Trauma

- Clotting disorders

- Severe dehydration

- Birth control pill

In more than 50% of cases, there is no cause identified. PVT predominantly affects young children, but it can occur in persons of any age. In adults, cancer is a common cause of PVT.

What is life expectancy after PVT?

If there is no liver disease or failure, then the risk of death is low. If bleeding occurs in the presence of liver failure, there is a high chance of dying within a year. More than 30% of individuals with bleeding and liver failure are dead within 2 years.

In children with PVT, the prognosis is much better overall, with a 10-year survival rate greater than 70%, which is attributable to the low incidence of underlying malignancy and cirrhosis.

How does portal vein thrombosis present?

The symptoms of PVT depend on whether the blood clot formation in the portal vein is sudden or a gradual process.

Acute: When the thrombus is acute, the condition is frequently missed. The signs and symptoms are vague. Patients can present emergently with:

- Sudden onset of right upper quadrant pain

- Nausea

- Fever

- Progressive ascites (fluid accumulation in abdomen)

- Intestinal ischemia resulting from propagation of thrombus, or lack of

Intestinal perfusion secondary to acute portal hypertension

- Occasionally, patients may vomit blood (if there is preexisting varices

With liver failure)

Chronic:Individuals with long standing PVT typically always present with vomiting of bright red blood. The amount of bleeding is frightening, even for the physician. Vomiting of blood usually occurs 3-4 years after the initial diagnosis. A few may develop fluid accumulation in the abdomen and others may develop confusion, memory and even coma.

When there is combined liver failure, the condition can deteriorate fast and lead to poor outcomes. When there is a cancer, most individuals do not vomit blood because patients do not survive that long.

Weight loss, loss of appetite, nausea and pain in the abdomen are other common features. Rarely, patients with portal vein obstruction present with a fever of unknown origin.

Can PVT resolve spontaneously?

Spontaneous resolution of the acute thrombus may occur and the symptoms improve. In others, the body may start to develop other vessels (collaterals) to by pass the blockage and the symptoms may not appear. The chronic variety never resolves on its own.

Do all individuals with portal vein thrombosis develop symptoms?

No. In about one third of people with portal vein thrombosis, blockage of the portal vein develops slowly, allowing other blood channels (collateral channels) to become established around the block.

How does one make diagnosis of portal vein thrombosis?

The physical exam and the presentation may give a clue. But if suspected, the diagnosis has to be confirmed by other tests.Diagnosis can be confirmed with:



Ultrasound, MRI or computed tomography (CT) scans may show the blockage. The diagnosis is confirmed by angiography (a dye is injected) and then x rays are obtained. This test is rarely done today because of the availability of CT and MRI

Liver biopsy: To confirm the diagnosis, a liver biopsy is required. This is done by inserting a small needle through the skin and obtaining a small piece of the liver.

Treatment

Acute Bleeding

Many times patients with severe vomiting of blood require urgent treatment and therapy is undertaken to prevent further bleeding.

Sclerotherapy: In the acute setting, treatment is most effective with variceal banding or sclerotherapy, often requiring several sessions to obliterate the bleeding. Both Sclerotherapy and/or banding require the use of a flexible camera placed in the swallowing tube (esophagus). The physician may then either apply a rubber band to ligate or inject the varices with a chemical. This has a success rate of 95% for the acute bleed.

Octreotide: Sometimes a chemical called Octreotide is administered. In the majority of individuals it stops the bleeding but recurrence is high with this approach.

Blood thinners: Sometimes if a recent blood clot has occurred, medications to dissolve the clot are administered. However, this is a very risky procedure because if vomiting of bright red blood is occurring at the same time, the blood thinner will make things worse. The majority of physicians stay away from this therapy because of the tendency to make the bleeding worse.

Surgery: The major aim of surgery is to prevent the thin walled varicosities from rupture and bleeding. There are many surgical techniques to treat these, but since most patients are in poor shape surgery is not a great option. In addition, surgery for PVT requires a multidisciplinary approach with a backup from many specialties. However, the surgery is of high risk and associated with many complications. Surgery is a last resort treatment because of availability of better non surgical methods. Whenever surgery is done in the presence of liver failure, the chances of death and complications are extremely high.

TIPS: Today, newer radiological techniques are available which can make a connection between the liver and the high pressure veins (shunt). This leads to decompression of the varices and a decrease in symptoms. The procedure is done in a radiology suite using x rays. However, TIPS is also associated with some complications which include:

- bleeding inside the abdomen

- failure of the shunt

- dead liver (infarction)

- re blockage of the shunt

The choice of TIPS over shunt surgery depends upon the expertise of the center in these techniques and the availability of a radiologist who is trained in this procedure. TIPS usually occludes over time and requires revision. However, TIPS has the advantage of being less invasive than shunt surgery.

Transplantation

Liver transplant is a great option for those with liver damage. However, the lack of donors and the difficult surgery has limited the option to a few individuals. It is probably the most effective treatment available. Survival is good after a liver transplant but one has to be on life long toxic chemotherapeutic drugs.

What are complications of untreated portal vein thrombosis?

- persistent vomiting of bright red blood

- collection of fluid in the abdomen (ascites)

- dead bowel

- worsening of the liver

- brain confusion, coma

- death

What is the prognosis of individuals with portal vein thrombosis?

Today, we have better treatments and the overall prognosis is good, with 75% of patients alive after 10 years and an overall mortality rate of less than 10%. However, in those individuals who have cancer or liver failure, the prognosis is poor.

Via: http://www.veindirectory.org

Hemodialysis for kidney failure: Is it right for you?

Find out what to expect if your doctor recommends hemodialysis. Learning more can help you decide if this treatment option fits your lifestyle.


Your kidneys contain millions of tiny blood vessels that filter waste from your blood and eliminate it in your urine. But diabetes and other diseases can damage this delicate filtering system. If your kidney function dips too low, your doctor may recommend dialysis.
There are two types of dialysis: hemodialysis and peritoneal dialysis. Either of these can bide time until a possible kidney transplant. If you're considering hemodialysis, here's what you need to know.

What is hemodialysis?

Hemodialysis is a procedure in which a machine filters harmful waste and excess salt and fluid from your blood. A needle is inserted into your arm through a special access point. Your blood is then directed through the needle to a machine called a dialyzer, which filters your blood a few ounces at a time. The filtered blood returns to your body through another needle.

Who needs hemodialysis?

If your kidneys are failing, you may need dialysis to help control your blood pressure and maintain the proper balance of fluid and various chemicals — such as potassium and sodium — in your body. Dialysis also helps your body maintain the proper acid-base balance.
Sometimes kidney failure is caused by a specific kidney disease. In other cases, it's a complication of another condition, such as:
  • Diabetes
  • High blood pressure (hypertension)
  • Kidney inflammation (glomerulonephritis)
  • Inflammation of blood vessels (vasculitis)
  • Polycystic kidney disease

How do you prepare for hemodialysis?

CLICK TO ENLARGE

Illustration of AV fistula for hemodialysis AV fistula for hemodialysis
Illustration of AV graft for hemodialysis AV graft for hemodialysis
Before you start hemodialysis, a surgeon creates a vascular access point for blood to leave for cleansing and then re-enter your body during treatment. There are three types of access points:
  • Temporary access. If you need emergency hemodialysis, the surgeon may insert a plastic tube (catheter) into a large vein in your neck or near your groin. The catheter is temporary. If it's left in place for too long, you face a risk of infection, clotting in the catheter and stenosis (narrowing) of surrounding blood vessels.
  • Arteriovenous (AV) fistula. A surgically created AV fistula is a connection between an artery and a vein, usually in the forearm. Once the connection is made, faster flowing arterial blood flows into the vein — causing it to grow larger and stronger. This makes repeated needle placements for hemodialysis easier. An AV fistula may take six weeks or longer to heal, but it can last for many years. An AV fistula is less likely than other types of access points to form clots or become infected.
  • Arteriovenous (AV) graft. If your blood vessels are too small to form an AV fistula, the surgeon may instead connect an artery and a vein with a synthetic tube. This tube functions like an artificial vein, usually in your forearm or upper arm. An AV graft often heals within two to three weeks. With proper care, an AV graft may last several years — but it's more likely to form clots and become infected than is an AV fistula.
Ideally, the access point is created weeks or even months before you need hemodialysis.

How do you care for the access point?

Vascular access is a vital part of hemodialysis. Take special care to prevent injury and infection:
  • Keep the access area clean.
  • Don't use the arm with the access point for blood pressure readings or to draw blood samples not associated with the dialysis treatment.
  • Don't lift heavy objects or put pressure on the arm with the access point.
  • Don't cover the access point with tight clothing or jewelry.
  • Check the pulse in the access point every day.
  • Ask the nurse or technician to check the access point before each treatment.
  • Don't sleep with the access arm under your head or body.
If your access point stops working, the surgeon can create a new access point in your other forearm, your upper arm or your groin. Or you may consider peritoneal dialysis, another type of dialysis done through a catheter inserted in your abdomen.

How often is treatment needed?

Most people receive hemodialysis three times a week, about three to five hours at each session. This type of hemodialysis, known as conventional hemodialysis, is usually done in a dialysis center. During each session you can read, watch TV, or do crossword puzzles or other sedentary activities.
At some dialysis centers, you can choose shorter but more frequent treatments. This is known as daily dialysis. It's usually done six days a week for about two to two and a half hours. Although conventional hemodialysis is more common, people who choose daily hemodialysis often report greater improvements in blood pressure and quality of life.

Can hemodialysis be done at home?

With special training and someone to help you, it's possible to do hemodialysis at home. If you're comfortable doing the procedure yourself and keeping records for your health care team, the benefits are appealing. Your quality of life will likely improve, you'll save yourself travel time to and from the dialysis center, and you'll have more flexibility about when to do your treatments — perhaps even at night while you sleep.

Is there a special diet for people on hemodialysis?

Eating the right foods can improve your dialysis results and your overall health. While you're receiving hemodialysis, you'll need to carefully monitor your intake of fluids, protein, sodium, potassium and phosphorus. Your dietitian will help you develop an individualized meal plan based on:
  • Your weight
  • Your personal preferences
  • How well your kidneys still function
  • Other medical conditions you might have, such as diabetes or high blood pressure

What about medication?

While you're receiving hemodialysis, you'll likely need various medications:
  • Blood thinners to prevent clots in the hemodialysis machine and tubing
  • Blood pressure medication to control your blood pressure
  • Erythropoietin to stimulate your bone marrow to produce new red blood cells
  • Calcium, iron and other nutritional supplements to control the level of certain nutrients in your blood
  • Phosphate binders to prevent the buildup of phosphorus in your blood
  • Stool softeners and laxatives to manage constipation
Your doctor will do frequent blood tests to monitor your condition.

What are the potential complications of hemodialysis?

Your kidneys play a role in many of your body's systems. When your kidneys stop working, these other systems don't work as well as they did before. This can lead to various complications, including:
  • Lack of red blood cells (anemia)
  • Bone diseases
  • High blood pressure
  • Fluid overload
  • Inflammation of the membrane surrounding the heart (pericarditis)
  • High potassium levels, which can affect your heart rhythm
  • Nerve damage
  • Infection
  • Heart disease
Dialysis of any type is a serious responsibility. Whether you choose to have hemodialysis at home or in a dialysis center — or you opt for peritoneal dialysis — your health is in your hands. Weigh the pros and cons of each treatment option with your health care team to help decide what's best for you.
Via: http://www.mayoclinic.com/health/hemodialysis

Vascular Access for Hemodialysis

If you are starting hemodialysis treatments in the next several months, you need to work with your health care team to learn how the treatments work and how to get the most from them. One important step before starting regular hemodialysis sessions is preparing a vascular access, which is the site on your body where blood is removed and returned during dialysis. To maximize the amount of blood cleansed during hemodialysis treatments, the vascular access should allow continuous high volumes of blood flow.

A vascular access should be prepared weeks or months before you start dialysis. The early preparation of the vascular access will allow easier and more efficient removal and replacement of your blood with fewer complications.

The three basic kinds of vascular access for hemodialysis are an arteriovenous (AV) fistula, an AV graft, and a venous catheter. A fistula is an opening or connection between any two parts of the body that are usually separate—for example, a hole in the tissue that normally separates the bladder from the bowel. While most kinds of fistula are a problem, an AV fistula is useful because it causes the vein to grow larger and stronger for easy access to the blood system. The AV fistula is considered the best long-term vascular access for hemodialysis because it provides adequate blood flow, lasts a long time, and has a lower complication rate than other types of access. If an AV fistula cannot be created, an AV graft or venous catheter may be needed.

What is an arteriovenous fistula?

An AV fistula requires advance planning because a fistula takes a while after surgery to develop—in rare cases, as long as 24 months. But a properly formed fistula is less likely than other kinds of vascular access to form clots or become infected. Also, properly formed fistulas tend to last many years—longer than any other kind of vascular access.

A surgeon creates an AV fistula by connecting an artery directly to a vein, frequently in the forearm. Connecting the artery to the vein causes more blood to flow into the vein. As a result, the vein grows larger and stronger, making repeated needle insertions for hemodialysis treatments easier. For the surgery, you’ll be given a local anesthetic. In most cases, the procedure can be performed on an outpatient basis.

Drawing of the underside of a forearm with an arteriovenous fistula. Arrows show the direction of blood flow. Two needles are inserted into the fistula. Labels explain that one needle carries blood to the dialysis machine and the other needle returns blood from the dialysis machine.
Forearm arteriovenous fistula.

What is an arteriovenous graft?

If you have small veins that won’t develop properly into a fistula, you can get a vascular access that connects an artery to a vein using a synthetic tube, or graft, implanted under the skin in your arm. The graft becomes an artificial vein that can be used repeatedly for needle placement and blood access during hemodialysis. A graft doesn’t need to develop as a fistula does, so it can be used sooner after placement, often within 2 or 3 weeks.

Compared with properly formed fistulas, grafts tend to have more problems with clotting and infection and need replacement sooner. However, a well-cared-for graft can last several years.

Drawing of an arm with an arteriovenous graft at the bend of the arm. Labels point to an artery and a vein. A curved tube, labeled looped graft, connects the artery to the vein. Arrows show the direction of blood flow from the artery to the vein through the looped graft.
One kind of AV graft.

What is a venous catheter for temporary access?

If your kidney disease has progressed quickly, you may not have time to get a permanent vascular access before you start hemodialysis treatments. You may need to use a venous catheter as a temporary access.

A catheter is a tube inserted into a vein in your neck, chest, or leg near the groin. It has two chambers to allow a two-way flow of blood. Once a catheter is placed, needle insertion is not necessary.

Catheters are not ideal for permanent access. They can clog, become infected, and cause narrowing of the veins in which they are placed. But if you need to start hemodialysis immediately, a catheter will work for several weeks or months while your permanent access develops.

Drawing of a venous catheter inserted through the skin near the collarbone. The catheter is connected to the large vein from the heart. The other end of the catheter branches into two portals.
Venous catheter for temporary hemodialysis access.

For some people, fistula or graft surgery is unsuccessful, and they need to use a long-term catheter access. Catheters that will be needed for more than about 3 weeks are designed to be tunneled under the skin to increase comfort and reduce complications. Even tunneled catheters, however, are prone to infection.

What can I expect during hemodialysis?

Every hemodialysis session using an AV fistula or AV graft requires needle insertion. Most dialysis centers use two needles—one to carry blood to the dialyzer and one to return the cleansed blood to your body. Some specialized needles are designed with two openings for two-way flow of blood, but these needles are less efficient. For some people, using this needle may mean longer treatments.

Some people prefer to insert their own needles, which requires training to learn how to prevent infection and protect the vascular access. You can also learn a “ladder” strategy for needle placement in which you “climb” up the entire length of the fistula, session by session, so you won’t weaken an area with a grouping of needle sticks.

An alternative approach is the “buttonhole” strategy in which you use a limited number of sites but insert the needle precisely into the same hole made by the previous needle stick. Whether you insert your own needles or not, you should know about these techniques so you can understand and ask questions about your treatments.

What are some possible complications of my vascular access?

All three types of vascular access—AV fistula, AV graft, and venous catheter—can have complications that require further treatment or surgery. The most common complications are access infection and low blood flow due to blood clotting in the access.

Venous catheters are most likely to develop infection and clotting problems that may require medication and catheter removal or replacement.

AV grafts can also develop low blood flow, an indication of clotting or narrowing of the access. In this situation, the AV graft may require angioplasty, a procedure to widen the small segment that is narrowed. Another option is to perform surgery on the AV graft and replace the narrow segment.

Infection and low blood flow are much less common in properly formed AV fistulas than in AV grafts and venous catheters. Still, having an AV fistula is not a guarantee against complications.

How should I take care of my vascular access?

You can take several steps to protect your access:

  • Make sure your nurse or technician checks your access before each treatment.
  • Keep your access clean at all times.
  • Use your access site only for dialysis.
  • Be careful not to bump or cut your access.
  • Don’t let anyone put a blood pressure cuff on your access arm.
  • Don’t wear jewelry or tight clothes over your access site.
  • Don’t sleep with your access arm under your head or body.
  • Don’t lift heavy objects or put pressure on your access arm.
  • Check the pulse in your access every day.
Via: http://kidney.niddk.nih.gov/Kudiseases

Arteriovenous Fistula

Who Performs the Procedure and Where Is It Performed?

The surgery to create an arteriovenous fistula for vascular access in hemodialysis is performed by a general surgeon or vascular surgeon in a hospital or one-day surgery center. It requires only local anesthesia and can be performed as an outpatient procedure.

Questions to Ask the Doctor

  • Why are you recommending an AV fistula instead of another kind of access?
  • How will an AV fistula make dialysis easier or better for me?
  • How often do you perform this procedure?
  • What will the fistula look like? Feel like?
  • Should I treat my fistula arm in any special way?
  • Are there activities I should avoid?
  • How long will the AV fistula last?

Arteriovenous (AV) fistula: What is it?

A-V fistula

A fistula is an abnormal connection between two parts of the body. An arteriovenous (AV) fistula refers to an abnormal connection between an artery and a vein.


An arteriovenous (AV) fistula is an abnormal passageway between an artery and a vein. Although it most often occurs in the legs or arms, an AV fistula can occur anywhere in the body, including the brain. An AV fistula may also be created surgically to provide access for hemodialysis in people with end-stage kidney failure.

Normally, your blood flows from arteries through capillaries and back to your heart in veins. When an AV fistula is present, blood flows directly from an artery into a vein, bypassing the capillaries. If the volume of diverted blood flow is large, tissues downstream receive less blood supply. In addition, heart failure may occur due to the increased volume of blood returned to the heart.

A doctor may suspect an AV fistula by an abnormal sound (bruit) heard over the artery with a stethoscope. The sound is due to turbulent blood flow between the artery and the vein. Small fistulas following injury sometimes close without treatment. But larger fistulas usually require treatment, which may include:

  • Endovascular coils inserted into the fistula to close it
  • Surgery to block the abnormal channel

Dialysis Fistula surgery

Saturday, November 22, 2008

3-year-old’s rare liver disorder cured

Doctors from the Indraprastha Apollo Hospital in Delhi have cured a three year old girl from a rare disease which prevented her from leading a normal life.

Fatima suffered from Crigler Najjar Syndrome (CNS), a rare and fatal liver disease.

Her only means of staying alive was phototherapy. Undressed she would be exposed to specific wavelengths oflight for 10-16 hours a day, every day.

Dr Subhash Gupta (liver transplant expert) and Dr Anupam Sibal (paediatrician) transplanted a part of Fatima’s father’s liver. That has brought the bilirubin level to normal heights.

“Very high levels of bilirubin can cause permanent brain damage. The main therapy for patients with this disease is phototherapy. Greater the surface area of the body that is exposed to light and greater the intensity of light falling on the skin, higher is the efficacy of phototherapy.

Fatima was living in agony, spending 10 to 14 hours every day under phototherapy since birth. This was severely restricting her lifestyle. Even travelling and vacations were a great problem.

Since the defect was with the liver, we decided to transplant part of the healthy liver of Fatima’s father into her. She will not require any more phototherapy. She will only have to be on medicines all her life, the dosages of which will lessen as she ages.

Both Fatima and her father are doing well. Her eyes and skin are no more yellow in colour.”
– Dr Gupta

Cured, Fatima has returned to her family in the Middle East and can start a normal life.

Via: http://www.goodnewsblog.com

High success rate for liver transplants at Delhi's Apollo

New Delhi: She came to Delhi from a Middle Eastern country with a rare disease and little hope of surviving. Three weeks later, this three-year-old girl left India with new hopes in her eyes, which had dramatically turned white from the deep yellow she was born with, fully cured and assured of living a normal life.

The girl, whose identity is being held back on family request, was born with a liver disorder leading to an enzyme deficiency.

According to Dr Anupam Sibal, medical director of Delhi's Apollo Hospital, the crigler najjar syndrome is found only in one child out of 0.162 million and if left untreated can even lead to death.

"She was in a very serious condition when she came to us," said Dr Sibal.

As it turned out, the problem was genetic. Three cousins from her mother's side had already died from this disease.

The only treatment in this case is a liver transplant. Her father was a willing donor since under the law only a family member can be a donor in cases of liver transplant.

Two teams of doctors, led by Dr Subhash Gupta carried out a difficult operation lasting over 12 hours to ensure this child could lead a normal life.

Delhi's Apollo Hospital has emerged as one of the most successful centres for liver transplant operations due to its high success rate which stands at 90 per cent and 100 per cent in cases of transplants done on children as well as being the most cost effective.

Compared to UK where a similar operation costs $150,000 (Dh551,000) and in US where it costs $300,000, the family had to pay the hospital less than $50,000. Apollo has undertaken 120 such operations in the past 18 months including 13 children, who have all returned home fully recovered.

"All liver transplant surgeries are rare considering there are just about 30-40 centres across the world which do about 100 transplants each every year," said Dr Gupta.

He took out 20 per cent of of her father's liver, although in some cases up to 60 per cent liver is taken out from the donor's body. Donor's liver grows back to its normal size within two weeks. The donor's liver was attached to the child's liver and all the tiny vessels were joined under a microscope, said D Gupta, adding that a few years ago such an operation was unimaginable.

Apollo Hospital has become as the most chosen for all liver transplants and at present five patients from the Middle East, including one from Dubai, are undergoing treatment here.

"She was unable to walk when she came to us. She had deep yellow eyes due to liver malfunction. By the time she left, she was able to walk and her parents had never seen her like before", Dr Sibal said.
Via: http://www.gulfnews.com/world/India

Thursday, November 20, 2008

Sonia Gandhi arranges for Pakistani boy’s liver transplant

New Delhi, November 19, 2008

Dr Subhash Gupta gives new life to another pakistani child.

Mobeen Ahmad lives in Lahore and is in on his first visit to Delhi. He loved the Red Fort, almost as much as cricket, which he is happy he can continue playing.

The 14-year-old nearly died of cirrhosis of the liver last month. A liver transplant was his only hope, and a transplant in Delhi’s Apollo Hospital helped him live.

After doctors in Pakistan had given up all hopes of his survival, his father Iftikar Ahmad approached Indian Congress President Sonia Gandhi for help.

“For a cook with a meagre income and 10 mouths to feed, raising 15 lakhs for surgery was impossible. Through a newspaper advertisement, the grievance cell raised money for the boys’ treatment,” said Archana Dalmia, head of Sonia Gandhi grievance cell.

Doctors at Apollo Hospital helped by waiving their fee, bringing down the treatment cost.

“When we first saw the boy, he had a bloated belly, yellow eyes, stunted growth and swollen nails. His liver was completely damaged and he had severe malnourishment. Before operating on him, it was imperative to restore his energy levels,” said Anupam Sibal, paediatric gastroentologist at Apollo.

A team led by liver transplant surgeon Dr Subhash Gupta did the surgery on October 21. His elder brother Bismil, 20, donated 40 per cent of his liver for the transplant. “Both the boys have recovered well and are ready to travel,” said Sibal.

Iftikar cannot contain his joy. “I have seen my boy sick since birth. Thanks to Srimati Gandhi who paid for the surgery and our travel costs, my son can realize his dreams of becoming a cricketer,” he said.

Via: http://www.hindustantimes.com

Nominate Liver Transplant In India Information Guide for Blog award

I want to ask for your support of Liver Transplant In India Information Guide, but also for all Liver Transplant/Kidney Transplant/Organ Donation in india, related awareness by nominating Liver Transplant InIndia Information Guide for the 2008 Weblogawards.

My hope is that sites like mine can earn mainstream attention to help bring awareness to the reality of living with Liver Transplant/Kidney Transplant and other related diseases.

Please visit Weblogawards and scroll down to the comment posted by

"Anshu Gupta"
"https://me.yahoo.com/a/ujTkw0t_k8vAtGh7owzrMES1W8aWPokARg--#c946a"
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nominating Liver Transplant In India Information Guide, then click on “+” rating (green button) to show your support for my nomination!

The 2008 Weblog Awards

Friday, November 7, 2008

"A large number of diseases are potentially treatable by liver transplants."

1) What diseases are treated by liver transplantation?
A large number of diseases are capable of interfering with the liver's function sufficiently to threaten the life of the patient and most are potentially treatable by liver transplantation.

2) Which liver diseases are the most common?
In adults, cirrhosis, the death of liver cells due to a variety of causes, is one of the most common reasons for which liver transplantation is done. In children, the disease most often treated by liver transplantation is biliary atresia, a failure of the bile ducts to develop normally to drain bile from the liver.

3) What about alcohol-related liver disease?
Many people who develop cirrhosis of the liver due to excessive use of alcohol do need a liver transplant. Abstinence from alcohol and treatment of complications for 6 months will usually allow some of them to improve significantly and these patients may survive for prolonged periods without a transplant. For patients with advanced liver disease, where prolonged abstinence and medical treatment fails to restore health, liver transplantation is the treatment.

4) And cancer of the liver?
Primary liver cancers develop at a significantly higher rate in cirrhotic livers as compared to normal livers. Particularly in patients having liver disease secondary to Hepatitis B. Liver Transplantation at an early stage of liver cancer may result in long-term survival for select patients.
However, cancers of the liver that begin somewhere else in the body and spread to the liver are not curable with a liver transplant.

5) Are there alternative treatments for liver disease?
There are effective medicines for some liver diseases, while for others only palliative treatment for complications is available. Treatment of complications may be all that is required if the liver is not failing. Frequently medical treatment delays, but does not eliminate, the need for transplantation.

6) Is liver transplantation a treatment of last resort, when everything else has failed?
Yes and no. If medical treatment is likely to allow prolonged survival with good quality of life, transplantation would be reserved for the future. However, ideally the surgery is undertaken before the terminal stage of the disease when the person is too ill to withstand major surgery. For patients with poor quality of life due to complications of liver cirrhosis liver transplantation should be undertaken at an optimal state of health in-order to avail good outcomes.

7) How is the decision made to transplant?
This is a decision made in consultation with all individuals involved in the patient's care, doctors as well as the patient’s family. The patient and family's input is vital and they must clearly understand the risks & benefits involved with proceeding to transplantation.

8) What are the major risks?
Before surgery, the risks are mainly the development of some acute complication of the liver disease, which might render the patient unacceptable for surgery. With transplantation there are risks common to all forms of major surgery, as well as technical difficulties in removing the diseased liver and implanting the donor liver. One of the major risks for the patient is not having any liver function for a brief period. Immediately after surgery, bleeding, poor function of the grafted liver, and infections are major risks. The patient is carefully monitored for several weeks for signs of rejection of the liver.

9) What are the overall chances of surviving a liver transplant?
This depends on many factors but overall 85 - 90 percent of children & adults survive and are discharged from the hospital.

10) How long does it take to recover?
In part this depends on how ill the individual was prior to the surgery. Most patients should count on spending a few days in an intensive care unit and about four weeks in the hospital, as a minimum.

11) What happens during this recovery period?
Initially in the intensive care unit there is very careful monitoring of all body functions including the liver. Once the patient is transferred to the ward, the frequency of blood testing, etc. is decreased, eating is allowed and physiotherapy is used to regain muscle strength. The drug or drugs to prevent rejection are initially given by vein, but later by mouth. During the transplantation, frequent tests are done to monitor liver function and detect any evidence of rejection.

12) If a transplanted liver fails to function, or is rejected, what can be done?
There are varying degrees of failure of the liver, however, and even with imperfect function, the patient will remain quite well. Occasionally, when circumstances and time permit, a failing transplanted liver can be replaced by a second (or even third) transplant. Unfortunately, there is no dialysis treatment for livers as is possible with kidneys. Researchers are experimenting with devices to keep patients with failing livers alive while waiting for a new liver.

13) What side-effects do patients commonly experience from the drugs used to treat or prevent rejection?
All the drugs used for rejection increase the person's susceptibility to infections (and possibly to the development of tumors). Various medicines are used, and each has its own effects. Cortisone-like drugs produce some fluid retention and puffiness of the face, risk of worsening diabetes and osteoporosis (a loss of mineral from bone). Cyclosporine produces some tendency to develop high blood pressure and the growth of body hair. The dose of this medication must be very carefully regulated. Kidney damage can occur from cyclosporine but this can usually be avoided by monitoring the drug levels in the blood. Common side effects for FK-506 include headaches, tremor, diarrhea, increased tension, nausea, increased levels of potassium and glucose and kidney dysfunction.

14) Do recipients of liver transplant have to take these medicines for the rest of their lives?
Usually. However, as the body adjusts to the transplanted liver, the amount of medicine needed to control rejection is reduced. There are patients who have been successfully taken off these drugs. Researchers are attempting to determine why this has been successful in these cases.

15) How frequent is medical follow-up?
Routine follow-up consists of monthly blood tests, measuring of blood pressure by a local physician with annual or semi-annual checkups at the transplant center.

16) Are patients more susceptible to other infections?
Recipients should avoid exposure to infections as the immune system is depressed. Illness should be reported to the doctor immediately and medicines taken only under medical supervision.

17) What about physical activity after a liver transplant?
Most patients are able to return to a normal or near-normal existence and can participate in fairly vigorous physical exercise six to twelve months after a successful liver transplant.

18) What about sexual activity?
As with other physical activities, sexual activity may be resumed.

19) Is it safe for women to become pregnant after transplantation?
Studies have shown that women who undergo liver transplantation can conceive and give birth normally, although they have to be monitored carefully because of a higher incidence of premature births.
Mothers are advised against nursing babies because of the possibility of immunosuppressive drugs being ingested by the infants through breast milk.

20) What about diet?
Transplant patients have a tendency to gain weight because of their retention of water. They are advised to lower their intake of salt to reduce or eliminate this water retention. Otherwise patients should maintain a balanced diet.

21) Can there be a recurrence of the original disease in the transplanted liver?
If the disease was caused by hepatitis B or hepatitis C viruses then recurrence is likely. Other types of liver disease do not recur.

22) From the description, patients with successful liver transplants seem very healthy. How long can this good health last?
The newness of this procedure makes this question difficult to answer. There is every indication that those who are well after one year remain so indefinitely.

23) Where do the donor livers come from?
Livers are donated, with the consent of the next of kin, from individuals who have brain death, usually as a result of a head injury or brain hemorrhage. When such a donor is identified, transplant centers are contacted by a computer network and arrangements are made to retrieve whatever organs may be donated. Frequently this involves a team from a transplant center flying to the donor hospital to remove the organs, and returning with them for the transplant operation.

24) Do the donor and the recipient have to be matched by tissue type, sex, age, etc.?
No. For liver transplants, the only requirements are that the donor and recipient need to be approximately the same size, and of compatible blood types. No other matching is necessary.

25) What happens if there are two suitable recipients for a donated liver?
This is unusual in practice but the decision would be to transplant the patient with the more urgent need.
No. For liver transplants, the only requirements are that the donor and recipient need to be approximately the same size, and of compatible blood types. No other matching is necessary. This is unusual in practice but the decision would be to transplant the patient with the more urgent need.

26) How can I donate my organs?
If you wish to be an organ donor, carry an organ donor card and place an organ donor sticker on your medical identification card. It is important to discuss organ donation with family members since they will have to give consent. An organ donor card is available from the MOHAN Foundation and at SGRH (Sir Ganaga Ram Hospital) Delhi.

FIRST-EVER LIVER TRANSPLANT IN UAE

Friday 7th Nov 2008

The first-ever liver transplantation in the UAE has been successfully carried out on an Asian patient at Zayed Military Hospital. Prakash Doshi, 46-year-old Indian businessman from Dubai who is a father of two, was suffering from advanced liver failure for the past three months and his health was deteriorating dramatically. In the delicate surgery a team of five surgeons used 60 per cent of his wife Bhavna Doshi’s liver to help save the patient’s life. The recipient is recovering in the Intensive Care Unit (ICU) at Zayed Military Hospital while the donor was transferred to the ward and is reported to be doing well, medical and official sources confirmed. Announcing the achievement to the media Dr Rashid Ahmed Al Nuaimi, Director, Medical Services at the Hospital, said that the operation will pave the way for setting up a centre for liver, pancreas and kidney transplant centre, which will spare both nationals and expatriates the hassles of going abroad for treatment.

Via:http://www.radianceweekly.com

Wednesday, November 5, 2008

Advanced Hepatobiliary Surgery

Procedures & Indications

Hepatobiliary and Pancreas

We, at the Center for Liver Diseases & Transplantation are committed to bringing new and advanced diagnostic tools, medical treatments and surgical options to the physicians and patients we serve. Through this procedure profile, our physicians illustrate surgical techniques and capabilities that provide you with a window into their practice of diagnosis, treatment and patient follow-up.

Surgical Capabilities | Biliary Tumors and Injuries | Diseases of the Pancreas - Surgical Options | Liver Cancer - Surgical Options | Why Choose Us? | For More Information | .
Surgical Capabilities

New diagnostic and surgical capabilities have enabled the Liver Center’s hepatobiliary team to better treat hepatobiliary and pancreatic carcinoma as well as other diseases affecting these organs. Our skilled hepatobiliary team -- comprised of surgeons, interventional endoscopists, radiologists and hepatologists -- works together to provide surgical treatment for the following problems:

Biliary
* Carcinoma of the gallbladder
* Malignant tumors of the bile duct
* Bile duct injuries and strictures
* Choledochal cysts
* Recurrent pyogenic cholangitis
Pancreas
* Pancreatitis
* Pancreatic pseudocyst
* Malignant neoplasms of the pancreas
* Cystic neoplasms of the pancreas
* Pancreatic islet cell tumors
Liver
* Hepatic trauma
* Metastatic neoplasms of the liver (Cancer originated elsewhere & spread to liver)
* Benign (Non cancerous) tumors and cysts of the liver
* Portal hypertension (portasystemic shunts)

With the use of laparoscopy and endoscopic ultrasound (EUS), all patients with malignancies are staged pre-operatively. Following staging, our hepatobiliary team works in conjunction with the referring physician to determine the treatment best suited for the patient's condition. Because choosing a treatment plan is an important decision, we review all options with patients and family members as well as their referring physician, explaining the benefits and disadvantages of each option.

Biliary Tumors and Injuries

Biliary surgery is most frequently performed for stones, strictures and tumors. Among the treatment options available at the Liver Center, Apollo include:

Resection of primary biliary neoplasms (cholangiocarcinoma
Treatment of bile duct cancer usually requires removal of the bile duct and possibly portions of the liver, gallbladder, pancreas and small intestine. After resecting the neoplasms -- either through open surgery or laparoscopically -- the surgeon reconnects the bile ducts to the small intestine for proper biliary drainage (see illustration).

Biliary Drainage Procedures

Biliary drainage procedures are performed when the bile duct becomes blocked, narrowed or injured. During surgery, continuity of the biliary tree is usually re-established via a hepaticojejunostomy.

Diseases of the Pancreas - Surgical Options
Upon referral of a suspected pancreatic pathology, the Liver Center’s hepatobiliary team initiates a pre-operative work up which usually includes an evaluation of the pancreas via EUS. This evaluation helps to determine the location of the pathology in the head, neck, body or tail of the pancreas.

Subsequent treatment options include:

Pancreaticoduodenectomy (Whipple Procedure)
A pancreaticoduodenectomy, also known as a Whipple procedure, involves the removal of the pancreas head due to a tumor in the pancreas or bile duct, or pancreatitis.

If a tumor exists in the head of the pancreas, it is usually necessary to remove the pancreas head, duodenum, gallbladder and a portion of the bile duct Figure 1). Sometimes, part of the stomach is also removed.

The end of a patient's bile duct and the remaining pancreas are then connected to the small bowel (Figure 2) to ensure flow of bile and enzymes into the intestines.

Distal Pancreatectomy (laparoscopic or open)
Indicated for tumors in the body and tail of the pancreas, a distal pancreatectomy involves the removal of cystic neoplasms either laparoscopically or with open surgery. With both laparoscopic and open distal pancreatectomy procedures, surgeons attempt to preserve the spleen.

Drainage Procedures

With chronic pancreatitis, a dilated pancreatic duct usually reflects obstruction. Procedures to improve ductal drainage include:

-Longitudinal Pancreaticojejunostomy (Puestow Procedure): The pancreatic duct is opened from the tail to the head of the pancreas and attached to the small bowel.
-Distal Pancreaticojejunostomy (Du Val Procedure): The pancreas is divided transversely at the neck, and the body and tail are drained via attachment to the small bowel.
-Sphincteroplasty: When endoscopic sphincterotomy is unsuccessful, surgical sphincteroplasty may be required of the minor or major papilla.

Pancreas Transplantation: A pancreas transplant is indicated for patients with insulin-dependent (Type 1) diabetes.

Liver Cancer - Surgical Options
When determining treatment options for tumors of the liver, the hepatobiliary team reviews the results of one's pre-operative evaluation and overall health to recommend appropriate treatment options. The majority of liver metastases come from the colon. The single tumor or more than one tumor confined to either left or right side of the liver can be successfully resected with 5-year survival as high as 60%.

Treatments for tumors of the liver include:

Surgical Resection (Tumor Removal) -- Open or Laparoscopic
Typically, surgeons can safely remove up to 70% of the liver (if there is no fibrosis) and expect full regeneration. During resection, the surgeon first uses ultrasound to determine the tumor(s) proximity to hepatic structures and then removes it with as little liver as possible, while ensuring a margin free of tumor.

For patients who may not have enough liver reserve, portal vein embolization is used pre-operatively.

This technique, which involves the insertion of tiny microspheres into the portal vein, blocks blood flow to the portion of the liver containing tumor(s), and results in the enlargement of the remaining liver segments on which the patient will depend after resection.

If the location of a benign tumor is superficial and small in size, the operation can be performed laparoscopically (by making small punctures in the abdomen while viewing through a video camera). We are one of the very few centers in South East Asia offering Laparoscopic Liver Resection.

The Center for Liver Diseases and Transplantation, Apollo is equipped with the state of the art technology related to liver surgery and using the laparoscopic ‘Argon Beam Laser’ as well as as ‘Tissue Link™’ in combination with other methods of liver resection like ‘CUSA™’ and ‘laparoscopic vascular stapling’, we ensure a very high rate of bloodless liver surgery at Apollo.

Liver Transplantation

While a liver transplant represents the best cure for most patients with non-metastic liver cancer, the limited organ supply may make this option unattainable. The eligibility criteria for transplantation is the presence of a single HCC tumor 5 cm. or less in diameter, or three or fewer tumor modules, each 3 cm. or less in diameter. Both living-related and cadaveric liver transplants are options for patients at the Center for Liver Diseases & Transplantation, Apollo.

Ablation (Radiofrequency or Cryoablation)
Patients who are not candidates for resection or transplantation due to inadequate liver reserve, large or multiple lesions in multiple lobes, fibrosis or cirrhosis can benefit from treatments such as CT-guided, laparoscopic or open radiofrequency or cryoablation.

With new radiofrequency (RF) ablation technology, liver tumors up to 7 cm. in diameter can be treated. The ideal patient for RFA generally has no more than three lesions that are no greater than 5 cm. (about 1.5 inch) in size.

RF ablation delivers radiofrequency energy to the tumor, heating it to temperatures above 113 degrees Fahrenheit and thereby destroying the lesion. During cryoablation, argon gas is delivered through probes inserted into the liver, creating an ice ball that freezes the tumor and destroys its cells (see illustration).

Percutaneous Ethanol Injection Therapy (PEIT)
Another option for patients who are not surgical candidates, PEIT involves the injection of alcohol into the tumor, causing immediate dehydration of the cytoplasm with consequent coagulation, necrosis and fibrous reaction. PEIT results in complete ablation in up to 75% of selected patients with hepatocellular carcinoma.

Hepatic Arterial Pumps
Indicated for patients with metastatic colon cancer, hepatic arterial pumps deliver chemotherapy to the liver through a catheter placed in the hepatic artery. The catheter is typically inserted via laparoscopic or open surgery and a pump, which delivers the chemotherapy, is implanted subcutaneously. The pump is generally filled with chemotherapy once a month.

Why Choose Us?
Apollo Center for Liver Disease & Transplantation offers comprehensive specialty care for diseases of the liver, pancreas and bile duct. We emphasize ongoing communication with referring physicians and incorporate them in the decision process of their patient's medical management. Following treatment, we follow up our care with an organized discharge report to the referring physician.

For patients requiring hospitalization, we have a dedicated hepatobiliary critical care unit, a heptobiliary physician on-call, anesthesia staff and a specialized O.R. nursing team. At the Liver Center, our focus is on providing experienced, personalized care for all our patients.

With the use of advanced technology and surgical methods, patients now have more options than ever for the treatment of hepatobiliary disease. Our physicians are trained at the world’s most renowned centers in Hepatobiliary surgery and Liver Transplantation and are actively involved in clinical research and offer multiple studies in areas such as hepatocellular carcinoma, gastroenterology and viral hepatitis. Additionally, our hepatobiliary team offers outreach ‘Liver Clinics’ in the various units of Apollo hospital, providing pre- and post-operative hepatobiliary care close to home in & around Delhi.

We welcome your inquiries regarding treatment options, outreach locations or referrals.

For further information on surgical options for advanced hepatobiliary and pancreatic diseases, please contact

Dr Subash Gupta
Liver Transplant Surgeon
Indraprastha Apollo Hospital
Sarita Vihar Delhi
Email: anscreativity@gmail.com

Diet & Nutrition in Liver Disease :: Nutrition guidelines

Diet & Your Liver



What does nutrition have to do with your liver?

Nutrition and the liver are interrelated in many ways. Some functions are well understood; others are not. Since everything we eat, breathe and absorb through our skin must be refined and detoxified by the liver, special attention to nutrition and diet can help keep the liver healthy. In a number of different kinds of liver disease, nutrition takes on considerably more importance.


Why is the liver so important in nutrition?

85-90% of the blood that leaves the stomach and intestines carries important nutrients to the liver where they are converted into substances the body can use.

The liver performs many unique and important metabolic tasks as it processes carbohydrates, proteins, fats and minerals to be used in maintaining normal body functions.

Carbohydrates, or sugars, are stored as glycogen in the liver and are released as energy between meals or when the body's energy demands are high. In this way, the liver helps to regulate the blood sugar level, and to prevent a condition called hypoglycemia, or low blood sugar. This enables us to keep an even level of energy throughout the day. Without this balance, we would need to eat constantly to keep up our energy.

Proteins reach the liver in their simpler form called amino acids. Once in the liver, they are either released to the muscles as energy, stored for later use, or converted to urea for excretion in the urine. Certain proteins are converted into ammonia, a toxic metabolic product, by bacteria in the intestine or during the breakdown of body protein. The ammonia must be broken down by the liver and made into urea which is then excreted by the kidneys. The liver also has the unique ability to convert certain amino acids into sugar for quick energy.

Fats cannot be digested without bile, which is made in the liver, stored in the gallbladder, and released as needed into the small intestine. Bile (specific bile "acids"), acts somewhat like a detergent, breaking apart the fat into tiny droplets so that it can be acted upon by intestinal enzymes and absorbed. Bile is also essential for the absorption of vitamins A, D, E, and K, the fat soluble vitamins. After digestion, bile acids are reabsorbed by the intestine, returned to the liver, and recycled as bile once again.



Can poor nutrition cause liver disease?

There are many kinds of liver disease, and the causes of most of them are not known. Poor nutrition is not generally a cause, with the exception of alcoholic liver disease and liver disease found among starving populations. It is much more likely that poor nutrition is the result of chronic liver disease, and not the cause.

On the other hand, good nutrition - a balanced diet with adequate calories, proteins, fats, and carbohydrates - can actually help the damaged liver to regenerate new liver cells. In fact, in some liver diseases, nutrition becomes an essential form of treatment. Patients are strongly advised not to take megavitamin therapy or to use nutritional products bought in special stores or by catalogue without consulting a doctor.


How does liver disease affect nutrition?

Many chronic liver diseases are associated with malnutrition. One of the most common of these is cirrhosis. Cirrhosis refers to the replacement of damaged liver cells by fibrous scar tissue which disrupts the liver's important functions. Cirrhosis occurs as a result of excessive alcohol intake (most common), common viral hepatitis, obstruction of the bile ducts, and exposure to certain drugs or toxic substances.

People with cirrhosis often experience loss of appetite, nausea, vomiting and weight loss, giving them an emaciated appearance. Diet alone does not contribute to the development of this liver disease. People who are well nourished, for example, but drink large amounts of alcohol, are also susceptible to alcoholic disease.

Adults with cirrhosis require a balanced diet rich in protein, providing 2,000 to 3,000 calories a day to allow the liver cells to regenerate. However, too much protein will result in an increased amount of ammonia in the blood; too little protein can reduce healing of the liver. Doctors must carefully prescribe the correct amount of protein for a person with cirrhosis. In addition, the physician can use two medications (lactulose and neomycin) to control blood ammonia levels.


What other nutritional problems are caused by cirrhosis?

When the scarring of cirrhosis interferes with the flow of blood from the the stomach and intestines to the liver, a condition called portal hypertension may develop. This simply means that there is back pressure in the veins entering the liver. Surgical "shunting", or rerouting of blood away from the liver and into the general circulation can relieve this pressure, but it often causes a new set of problems. Because the shunted blood has bypassed the liver, it contains high levels of amino acids, ammonia, and possibly toxins. When these compounds reach the brain, they cause a condition called hepatic encephalopathy, which means "liver caused mental impairment." Patients become confused and some temporary loss of memory occurs.


Can diet help in treating other complications of cirrhosis?

There are a number of complications of cirrhosis which can be helped through a modified diet.

Persons with cirrhosis often experience an uncomfortable buildup of fluid in the abdomen (ascites) or a swelling of the feet, legs, or back (edema). Both conditions are a result of portal hypertension (increased pressure in the veins entering the liver). Since sodium (salt) encourages the body to retain water, patients with fluid retention can cut their sodium intake by avoiding such foods as canned soups and vegetables, cold cuts, dairy products, and condiments like mayonnaise and ketchup. In fact, most prepared foods contain liberal amounts of sodium, while fresh foods contain almost no sodium at all. A good-tasting salt substitute is lemon juice.



Are there other liver diseases where specific changes in diet can help?

Nutrition and a modified diet have been found to have a significant effect on a number of other liver diseases. Some types of liver disease, for example, cause a backup of bile in the liver which is called cholestasis. This means that bile cannot flow into the small intestine to aid in the digestion of fats. When this happens, fat is not absorbed but instead is excreted in large amounts in the feces, which become noticeably pale-colored and foul-smelling. This condition is known as steatorrhea. This loss of fat calories may also cause weight loss.

Special fat substitutes, such as medium chain triglycerides (MCT oil) and safflower oil can help alleviate this condition because they are less dependent on bile for intestinal absorption. They can be used like other oils in cooking, baking and salad dressings.

Patients with steatorrhea may also have difficulty absorbing fat soluble vitamins A, D, E, K. However, water soluble vitamins are absorbed normally. Supplementing the diet with fat soluble vitamins is possible, though it should only be carried out under the guidance of a physician. Vitamin A in excess over what is needed is very toxic to the liver.



Diet for liver disease


A healthy liver is like a processing plant. Carbohydrates, proteins, fats, vitamins, and minerals all go to the liver where they are broken down and stored. Later, they are remade into whatever the body needs and carried through the bloodstream to wherever they will be used.

Even when the liver is damaged, these nutrients still come to the liver after they have been digested. But, once they arrive, the liver cannot process them and they build up. This build-up causes more liver damage.

As a result, what a person with liver disease eats is very important. This diet needs to provide nutrients without causing further harm to the liver. This type of diet would include:

  • A limited amount of protein. A damaged liver cannot process protein very well. This causes a build-up of ammonia in the bloodstream.

  • Sore carbohydrate. Carbohydrate is the body's energy supply. A healthy liver makes glycogen from carbohydrate. The glycogen is then broken down when the body needs energy. A damaged liver can't do this. Without glycogen, more carbohydrate is needed from the diet to make sure the body has enough energy.

  • A moderate amount of fat. Fat provides calories, essential fatty acids, and fat-soluble vitamins.

  • A limited amount of fluids and sodium. Liver damage can cause high blood pressure in the major vein of the liver. This can result in ascites, a fluid build-up in the abdominal cavity. Limiting fluids and sodium can help prevent this.

  • Extra amounts of certain vitamins and minerals. A damaged liver has problems storing many vitamins and minerals.

Liver "sluggishness" is often blamed for poor appetite, listlessness, poor digestion and bad health. In fact, only in a minority of instances, is the liver to blame in these situations.
Specifically, only in liver disease which may take the form of hepatitis or cirrhosis will ill-health be due to the liver.

Diet For A Healthy Liver

A balanced diet with plenty of fruits, vegetables, animal protein with a fat - carbohydrate - protein ratio of 30% - 50% - 20% unless specific problems such as diabetes, kidney disease etc dictate otherwise. ·

  • Plenty of fluids
  • Avoidance of excess alcohol
  • Pack your diet with antioxidants

Anti-oxidants protect against free radical (produced in all of us due to body's metabolic processes) injury. Apart from protecting the liver and helping in its recovery if damaged, they have been shown to inhibit cancer cells, fight the ageing process and protect the sight.

Antioxidants are abundant in fruits and vegetables, as well as other foods including nuts, grains and some meats, poultry and fish. Below are some of the anti-oxidants and their best food sources.

Beta-carotene
Found in many foods that are orange in color, including sweet potatoes, carrots, apricots, pumpkin, and mangos. Some green leafy vegetables such as spinach and kale are also rich in beta-carotene.

Lycopene
A potent antioxidant found in tomatoes, watermelon, guava, papaya, apricots, oranges

Selenium
Selenium is a mineral, not an antioxidant nutrient. However, it is a component of antioxidant enzymes. The amount of selenium in soil, which varies by region, determines the amount of selenium in the foods grown in that soil. Plant foods like rice and wheat are the major dietary sources of selenium in most countries

Vitamin A
Foods rich in vitamin A include liver, sweet potatoes, carrots, milk, egg yolks and mozzarella cheese.

Vitamin C
This can be found in abundance in citrus fruits (lemons, oranges etc.), cereals, poultry and fish.

Vitamin E
This is found in almonds, in many oils including safflower, corn and soybean oils, and also found in mangos, nuts, broccoli and other foods.

A host of over-the-counter anti-oxidant preparations such as Salymarin (milk thistle) can be taken although unnecessary if above foods are taken in good quantities.



What is a liver disease diet?

The liver is an organ in the body that does several important tasks. One task of the liver is to help the body use the nutrients in food for energy. Liver diseases such as hepatitis and cirrhosis may change the way your body uses nutrients from food. Nutrients include carbohydrate (kahr-boh-HEYE-drayt), protein, fat, vitamins and minerals. Some people with liver disease may not get enough nutrients and lose weight because of these changes.

A liver disease diet provides the right amount of calories, nutrients, and liquids for you. A liver disease diet may help your liver work better and prevent other health problems. The dietary changes you will need to make depend on the type of liver disease and health problems you have. Your dietitian (di-uh-TISH-in) or nutritionist (noo-TRI-shun-ist) will tell you about the type of diet that is best for you.



What can I do to make a liver disease diet part of my lifestyle?

Changing what you eat and drink may be hard at first. You may need to make these changes part of your daily routine. Following a liver disease diet may help you feel better.

Choose a variety of items on this diet to avoid getting tired of having the same items every day. Keep a list of items allowed on this diet in your kitchen to remind you about the diet.

Carry a list of items allowed on this diet to remind you about the diet when you are away from home. Tell your family or friends about this diet so that they can remind you about the diet.

Ask your caregiver, a dietitian, or a nutritionist any questions you may have about your diet plan. A dietitian or nutritionist works with you to find the right diet plan for you. These caregivers can also help to make your new diet a regular part of your life.



What should I avoid eating and drinking while on a liver disease diet?

The foods that you need to avoid or limit depend on the type of liver disease and health problems you have. Following are some of the dietary changes that you may need to make:

Sodium: You may need to decrease the amount of sodium in your diet. Sodium causes your body to retain (hold on to) fluids. When your body holds on to fluids, you will have swelling. Your caregiver may suggest that you limit or avoid high-sodium foods. Your caregiver will give you more information about a low-sodium diet. Some foods that contain high amounts of sodium are the following:

  • Bacon, sausage and deli meats.
  • Canned vegetables and vegetable juice.
  • Frozen dinners.
  • Packaged snack foods like potato chips and pretzels.
  • Soy, barbecue, and teriyaki sauces.
  • Soups.
  • Table salt.

Liquids: You may also have to drink fewer liquids if you have swelling. Liquids include water, milk, juice, soda, and other beverages. It also includes any food that contains liquid, such as soup. This also includes food that melts when it is not cold, such as gelatin. Talk to your caregiver about the amount of liquid you may drink each day.

Alcohol: Alcohol may make your liver disease worse. Avoid alcoholic drinks such as beer, wine, hard liquor (whiskey, gin, vodka) or mixed drinks (drinks made with hard liquor). Talk to your caregiver if you have questions about alcohol in your diet.



What can I eat while on a liver disease diet?

Eat ____ grams of protein each day.

Eat ____ grams of sodium each day.

Drink ____ ounces of liquid each day.

Calories: Eat a variety of foods each day to help your liver work as well as possible, and to keep a healthy weight. You may not feel hungry or you may feel full right away after eating. This may make it hard for you to eat enough calories. Eat several small meals throughout the day instead of large meals to make sure you eat enough calories. Ask your dietitian or nutritionist how many calories you need each day.

Protein: It is important to eat the right amount of protein when you have liver disease. Your dietitian or nutritionist will tell you how much protein you should have each day. The following foods are good sources of protein. The amount of protein (in grams) follows each listed food.

  • Three ounces of meat, poultry (chicken), or fish (21 grams).
  • One cup of milk or yogurt (eight grams).
  • One large egg (seven grams).
  • Two tablespoons of peanut butter (seven grams).
  • One-half of a cup of tofu (seven grams).
  • One-fourth of a cup of cottage cheese (seven grams).
  • One ounce of cheese (seven grams).
  • One-half of a cup of cooked, dried, pinto, kidney or navy beans (three grams).

Fat: Your caregiver will tell you how much fat you should have in your diet each day. Some people with liver disease have problems with digesting (breaking down) and absorbing (using) fat. The fat that is not broken down and used by the body is lost in bowel movements. If you have this health problem, you may need to eat less fat. Your doctor may also suggest that you eat a special type of fat that is absorbed more easily by your body.

Carbohydrates: Your caregiver will tell you how much carbohydrate you should eat each day. Carbohydrates are found in breads, cereals, grains (rice, oats), starchy vegetables (potatoes, corn, peas), and crackers. Liver disease may cause blood sugar levels to be too high or too low in some people. You may need to make changes in your diet if you have this problem. Eating certain amounts of carbohydrates at each meal helps to control blood sugar levels.



What other diet guidelines should I follow?

Talk to your caregiver before taking any vitamins or herbal supplements (pills).

Talk to your dietitian or nutritionist about any other diet changes you should make. Liver disease may cause several different health problems. Your caregiver may suggest that you make other diet changes that can help to improve your health.

Risks:

You may not get enough nutrients and lose weight if you do not eat a balanced diet. Not following a liver disease diet may cause certain health problems to become worse.

Liver disease may cause you to lose your appetite and feel full too quickly after eating. This may make it hard for you to eat enough calories. Talk to your caregiver if you are having trouble eating and drinking.

Care Agreement:

You have the right to help plan your care. To help with this plan, you must learn about your diet. You can then discuss treatment options with your caregivers. Work with them to decide what care may be used to treat you. You always have the right to refuse treatment.





Eat for health

Since everything we eat must pass through the liver, special attention to nutrition and diet can help keep me healthy. Here are some tips on eating for health healthy liver, healthy you!

Eat a well balanced, nutritionally adequate diet. if you enjoy foods from each of the four food groups, you will probably obtain the nutrients you need.

Cut down on the amount of deep-fried and fatty foods you and your family consume. Doctors believe that the risk of gallbladder disorders (including gallstones, a liver-related disease) can be reduced by avoiding high-fat and cholesterol foods.


Minimize your consumption of smoked, cured and salted foods. Taste your food before adding salt! Or try alternative seasonings in your cooking such as lemon juice, onion, vinegar, garlic, pepper, mustard, cloves, sage or thyme.

MEAT, FISH, POULTRY & ALTERNATIVES PROVIDE:
protein, vitamin A, iron, vitamin B12, niacin, fiber, thiamin

BREADS AND CEREALS PROVIDE:
carbohydrates, niacin, thiamin, iron, riboflavin, fiber

FRUITS AND VEGETABLES PROVIDE:
vitamin A, vitamin C, iron, fiber, folacin

MILK AND MILK PRODUCTS PROVIDE:
calcium, riboflavin, niacin,folacin, vitamin A, vitamin B12, vitamin D

Increase your intake of high-fiber foods such as fresh fruits and vegetables, whole grain breads, rice and cereals. A high-fiber diet is especially helpful in keeping me healthy.

Rich desserts, snacks and drinks are high in calories because of the amount of sweetening (and often fat) they contain. Why not munch on some fruit instead?

Keep your weight close to ideal. Medical researchers have established a direct correlation between obesity and the development of gallbladder disorders.

Vegetarianism and The Liver

The liver has been described as a chemical workshop of the human body. All the nutrients and other substances absorbed from the intestines pass through the liver before entering into the systemic circulation. Thus the liver is vulnerable to the damage caused by a host of infections and toxic agents. Several types of viruses and alcohol are by far the commonest of these agents. The impairment of the liver function usually manifests as jaundice. Persistent infection and continuing impairment of function may be followed by death unless these changes can be controlled.
The morphological changes in liver damage can manifest as fatty liver, hepatitis, cirrhosis of the liver and cancer of the liver.
A well planned dietary regimen is of utmost importance in the prevention and treatment of most hepatic disorders. It has been proved beyond doubt that some of the proteins derived from animals are responsible for producing persistent symptoms related to liver disease. Thus vegetarian diet, as mentioned below, has gained momentum in the treatment of hepatic disorders.

Viral Hepatitis
Since there are no antiviral agents against hepatitis,rest, abstinence from alcohol and dietary modifications form the mainstay of the treatment. Most patients have nausea and lack of appetite. They should be served with attractive and well cooked foods. Small meals served separately will be better tolerated than three large meals. A diet containing approximately 2000 kcal which can be provided by 20-25 gms fat, 80-90 gms pro teins and 400 gms carbohydrate is suitable. This requirement can be fulfilled by glucose, sugar, fruits, fruit juices, bread, cereals, vegetables, salads, jelly, jam, rice, boiled potatoes and puddings made with cereals and sugar. Though diets high in their fat content do not ultimately influence the course of the disease they are poorly tolerated by jaundiced patients. Fried food, milk and butter cause dyspepsia and should be avoided. Thus a vegetarian diet is better tolerated by the patients suffering from viral hepatitis.

Cirrhosis of Liver
Most of the patients of cirrhosis of liver are severely malnourished and require a high calorie and high protein diet. A high protein diet, particularly if derived from animal proteins, carries a high risk of precipitating hepatic encephalopathy. The best source of vegetarian proteins is milk, its products and Casilan. Choline present in foods like wheat germ, soyabean, peanuts and skimmed milk may prevent the formation of a fatty liver. It is also believed that cerebral disturbances due to liver damage are caused by the type of protein in the diet. Cirrhotic diet prescribed in a standard Indian books on diet and nutrition does not contain proteins derived from animal sources. A diet high in carbohydrate and proteins low in fat and fortified with vitamins would be most suitable. Thus a vegetarian diet is more suited to patients having cirrhosis of liver.

Ascites
In terminal stages of cirrhosis fluid accumulates in the abdominal cavity due to failure of the liver to synthetize plasma albumin. For such patients, a high protein diet which is low in sodium would be most suitable. But since these patients have no appetite, milk is the only practical diet which can supply the above requirements.
Finally when the liver fails - the condition is known as hepatic encephalopathy. There is a strong incidence of animal protein intake increasing the incidence of hepatic encephalopathy. The clinical features of this syndrome are sleep disturbances, restlessness, drowsiness, impaired intellectual function, confusion and stupor progressing to coma. Significant number of these patients develop chronic encephalopathy and can be managed successfully at home. They should be given 20 gms of protein in the diet. This should mainly be derived from skimmed milk.

Thus, it is very obvious that a vegetarian diet is more useful in the treatment of all liver disorders including the last stage of liver failure.

Support Liver Detoxification With Your Diet

Your liver plays a complex role in many critical functions in your body. A one-word summation of its task could be "detoxification." If there are nutritional deficiencies in your diet, your liver will have difficultly eliminating toxins, which will in turn increase the amount of toxins produced by your body.

Toxins and your liver

Toxins come from variety of sources. They come from the environment, the content of our bowels, the food we eat, the water we drink, and the air we breathe. If you are exposed to chemicals or cigarette smoke, it is your liver's job to clean up the toxins before they do damage.

The liver removes toxins in three ways:

  • It filters the blood.
  • It neutralizes toxins by excreting fat-soluble toxins with cholesterol through making bile.
  • It breaks down toxins with enzymes in a two-step process usually referred to as phase I and phase II detoxification.

A good diet helps your liver detoxify

To support proper liver function, it is important to eat a healthy diet that includes a variety of vegetables, which provide a wide range of essential nutrients. Your liver needs these nutrients to perform its duties. Some of the best things you can do for your liver include:

Eat a high-fiber diet. Fiber binds to the bile in the large intestines, which helps to transport it out of the body. This is one of the ways the body eliminates fat-soluble toxins from the body.

Include variety in your diet. Eat a wide variety of nutrient-rich foods, including foods high in antioxidants (vitamin C, beta carotene and vitamin E) and high in B vitamins, calcium, and trace minerals to protect the liver from damage and help it do its job.

Watch your B vitamins. Make sure to get enough choline, betaine, methionine, vitamin B6, folic acid and vitamin B12. These special nutritional factors are needed to promote liver decongestion, improve liver function and metabolize fat.

Use a medically supervised fast to aid in detoxification. A fast can quickly increase elimination of waste and enhance your body's healing processes. Fasting is not right for everyone, however; talk to your doctor to learn what fast is appropriate for you.

Important nutrients for your liver

A diet high in fiber includes a wide variety of plant-based foods. The best way to increase fiber is to eat more vegetables, beans and fruit. Foods that contain vitamins C and E are important as antioxidants to protect and treat a damaged liver. B vitamins are often depleted when the liver is overworked from alcohol consumption or toxic exposure. Methionine and cysteine are sulfur-containing proteins that are known to protect the liver and aid in converting fat-soluble toxins to water-soluble substances that can be eliminated through the urine. Choline is needed to metabolize fats in the body. Foods that contain these vitamins include:

Vitamin C. Rose hips, kale, parsley, collard greens, mustard greens, cauliflower, red cabbage, strawberries, papaya, spinach, kiwi fruit, citrus fruits, asparagus, mangos, peppers, broccoli, and Brussels sprouts.

Vitamin E. Almonds, filberts, sunflower seeds, avocados, asparagus, walnuts, tomatoes, whole grains, and green leafy vegetables.

B-complex. Nutritional yeast, sunflower seeds, almonds, peanuts, pine nuts, sesame seeds, buckwheat, wild rice, and brown rice.

Methionine and cysteine. Egg yolks, red peppers, garlic, onions, broccoli, Brussels sprouts, sesame seeds, whole grains and beans.

Choline. Soybeans, egg yolks, nutritional yeast, fish, peanuts, cauliflower, lettuce, cabbage, lentils, chick peas and brown rice.

Making specific dietary changes to aid your liver in detoxification can be simple. Eating a wide variety of organic vegetables, fruits, seeds, nuts, beans and whole grains gives your body the fiber and the nutrients it needs to protect and support healthy liver function.